← Issue №10/ week of Sep 6, 2026/Endoscopy

Submucosal Lidocaine Injection in Colonic Endoscopic Submucosal Dissection: A Single-Center, Double-Blind, Randomized Controlled Trial.

From GI Signals issue №10: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Endoscopy rct · n=110 · Sep 1, 2026 · Dig Endosc · IF 5.2

Submucosal Lidocaine Injection in Colonic Endoscopic Submucosal Dissection: A Single-Center, Double-Blind, Randomized Controlled Trial.

New evidenceESDcolorectal cancerendoscopy qualitysedation
Clinical takeawayConsider adding 1% lidocaine with 0.6% sodium alginate to submucosal injection fluid during colonic ESD to reduce spasms and antispasmodic use, particularly in cases with anticipated technical difficulty.
What it foundSubmucosal lidocaine injection (1% lidocaine with 0.6% sodium alginate) reduced severe spasms during colonic ESD compared to saline with 0.6% sodium alginate (34.6% vs 74.1%) and cut median antispasmodic doses from 2 to 1, without increasing adverse events.
ContextConfirms prior small studies suggesting lidocaine's antispasmodic effect in ESD, though without significant procedure time reduction in this adequately powered trial.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Ueda T … Seno H · Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society · IF 5.2 · PubMed ↗Permalink
← Read the whole of issue №10 Every paper GI Signals surfaces gets a page like this one. All issues