Colorectal
Signal score, how each part rates
ActionabilityPrevalenceStakesEvidence strengthNovelty
See the full rubric →Long non-coding RNAs in colorectal cancer: shaping the tumour microenvironment and advancing precision oncology.
Clinical takeawayNo clinical action yet: a mechanistic review of lncRNAs in CRC TME, proposing potential biomarkers and therapeutic strategies without human data.
What it foundLong non-coding RNAs (lncRNAs) regulate colorectal cancer (CRC) tumor microenvironment (TME) via immune modulation, vascular remodeling, and extracellular matrix dynamics, with dual roles as oncogenes or tumor suppressors.
ContextExpands understanding of CRC biology by detailing lncRNA roles in TME, but remains preclinical with no direct clinical validation.
Emergingsuggested applicable standard· U.S. Multi-Society Task Force on Colorectal Cancer (Rex DK, Boland CR, Dominitz JA, et al.), "Colorectal Cancer Screening: Recommendations for Physicians and Patients From the U.S. Multi-Society Task Force on Colorectal Cancer," Gastroenterology, 2017
Decision at stakethe potential for lncRNAs to inform future colorectal cancer screening or therapeutic strategies
U.S. Multi-Society Task Force on Colorectal Cancer (Rex DK, Boland CR, Dominitz JA, et al.), "Colorectal Cancer Screening: Recommendations for Physicians and Patients From the U.S. Multi-Society Task Force on Colorectal Cancer," Gastroenterology, 2017 · reviewed 2026-07-23 ↗Begin average-risk colorectal cancer screening at age 45 using a patient-centered shared-decision modality choice, colonoscopy every 10 years (preferred) or annual FIT as Tier 1 options, with multi-target stool DNA every 3 years, CT colonography every 5 years, or flexible sigmoidoscopy every 5 to 10 years as Tier 2 alternatives. A positive stool-based test requires diagnostic colonoscopy, and stool tests should not be ordered for patients who would decline follow-up colonoscopy. Generally stop at age 75 with individualized decisions for ages 76-85 and no screening beyond 85.
Bartolini M … Lenz HJ · Nature Reviews Gastroenterology & Hepatology · IF 57.5 · PubMed ↗